Harvick out-dueled Joey Logano for a lap on a restart with nine of 160 laps to go and then held on to win his second career Brickyard 400 victory at Indianapolis Motor Speedway.
Just like his win at the Brickyard in 2003, Harvick won the race from the pole.
The win is Harvick’s third in the Monster Energy NASCAR Cup Series this season and 48th of his career.
"This is great. I have to say thanks to all the fans. I can't tell you how much coming to Indianapolis means to me," Harvick said. "As a kid I watched Rick Mears win the Indy 500 and got to be around him as a kid. He was my hero.
"My team built a great race car. I can't say enough about everyone on (this team). They built a heck of a race car. It's the same stuff that we took to Michigan and had a real good weekend there, obviously, and went to Victory Lane.
"I know how much this means to Rodney (Childers, crew chief) and all the guys who work on this car. We've been so close at winning here before."
Asked what his second Brickyard wins means, Harvick said: "I know how much it means to everyone on our team. All these guys that make this car go around. I know how much it means to really everybody. And now baby girl (daughter Piper) gets a trophy."
Bubba Wallace finished a surprising third, William Byron was fourth and Clint Bowyer ended up fifth.
Rounding out the top-10 were Denny Hamlin, Ryan Blaney, Ryan Newman, Chase Elliott and Paul Menard.
Joining Harvick in the Cup series playoffs this season are Kyle Busch, Logano, Hamlin, Martin Truex Jr., Brad Keselowski, Kurt Busch, Elliott, Kyle Larson, Blaney, Alex Bowman, Erik Jones, Byron, Aric Almirola, Clint Bowyer and Ryan Newman.