Hamlin led on the restart to the second overtime and the battle on the final lap ended up involving Newman, Ryan Blaney and Hamlin.
Blaney got into Newman, sending him into the wall and into the car and his car was then hit again by Corey LaJoie. Meanwhile, Hamlin drag-raced with Blaney to the finish with Hamlin edging him at the finish line.
Safety crews worked to turn Newman’s No. 6 Ford upright and Fox Sports reported that once Newman was extracted from the car, he would immediately be taken to a local hospital.
It’s the second consecutive Daytona 500 victory for Hamlin and third overall (his other was in 2016).
Blaney ended up second, Chris Buescher was third, David Ragan was fourth and Kevin Harvick credited with fifth.
Following the break between Stages 2 and 3, all of the lead-lap cars elected to pit with Hamlin the first off pit road.
During the pit stops, Martin Truex Jr. slammed into a fuel can left on pit road by another driver and may have suffered some damage to the nose of his car. It turned out to be Chase Elliott’s gas can and Elliott had to restart the race from the rear of the field.
The race returned to green on Lap 137, Hamlin was followed by Blaney and Joey Logano. Blaney quickly moved into the lead on the restart with a push from Logano.
On Lap 138, Ricky Stenhouse Jr. grabbed the lead thanks to a push from Ross Chastain. Logano shoved Blaney back in front on the next lap.
Kyle Busch took a turn at the lead with Johnson in tow on Lap 141.
Drafting with Blaney, Brad Keselowski powered his way up to the lead on Lap 149, breaking up the Toyota grip on the front of the pack.
On Lap 161, Stenhouse was penalized for passing below the yellow line on the backstretch and was penalized by NASCAR and had to make a pass-thru on pit road.
With 37 to go, Logano had moved out to the lead, followed by Keselowski and Aric Almirola.
Ford and Toyota drivers elected to make their green-flag pit stops with 30 laps remaining, which allowed Johnson to move into the lead.
On Lap 171, Stenhouse wrecked off Turn 4 after contact with Jones and ended up on pit road as NASCAR elected not to call a caution and keep the race under green.
The remaining Chevrolets who had not pit made their final stop with 26 laps to go.
With 25 laps remaining, Kyle Busch cycled into the lead followed by Logano and Keselowski.
On Lap 181, Kyle Busch began dropping back in the field with smoke pouring out of the back of his No. 18 Toyota and he was forced to head to pit road under green.
With 16 laps remaining, Logano appeared to get into the back of Almirola, who then turned Keselowski, which ended up triggering a massive accident on the backstretch, collecting numerous contenders for the win including Jimmie Johnson, Alex Bowman, Blaney and others.
The race was immediately placed under a nearly 12-minute red flag to clean the track of debris. “I feel like we had a really good car. Made one mistake about a lap earlier. I should’ve covered the bottom better and didn’t,” Keselowski said. “It’s my fault I kind of put myself in position for that.”
Once the race returned to caution, smoke again poured out of Kyle Busch’s No. 18 Toyota and he was forced to take it to the garage.
The race returned to green with 10 laps remaining with Newman out front followed by Bell, Elliott, Logano and Hamlin.
With eight laps remaining, a three-car incident erupted on the backstretch involving Timmy Hill, Reed Sorenson and Bowman to bring out a caution.
The race restarted with four laps to go with Newman out front followed by Logano and Hamlin.
With two to go, Chastain attempted to go three-wide, tagged Ryan Preece and shot up the track and into the wall to place the race under caution again and send it into overtime.
After a red-flag to clean the track of debris, the race returned to green with Hamlin out front followed by Buescher, Harvick, Newman and Clint Bowyer.
Michael McDowell got into the back of Bowyer on the restart on the frontstretch to immediately place the race back under caution and into a second overtime.
The race returned to green with Hamlin still leading followed by Newman, Buescher, Blaney and Harvick.